摘要 |
Novel fused polycyclic heterocycle derivatives having excellent antitumor effects and a process for producing the same. A compound represented by the following general formula (I) or pharmacologically acceptable salts thereof: <CHEM> wherein the ring A represents an optionally substituted monocyclic aromatic ring or a dicyclic fused ring in which at least one of the rings is an aromatic ring; the ring B represents pyrrole, 4H-1,4-oxazine, 4H-1,4-thiazine or 4(1H)-pyridone; the ring C represents an optionally substituted, monocyclic or dicyclic fused aromatic ring; and Y represents a group represented by the formula -e-f (wherein e represents a lower alkylene; and f represents amidino, guanidino or amino optionally substituted by optionally hydroxylated or optionally lower-alkylaminated lower alkyl; provided that the cases where the rings A and B are both optionally substituted monocyclic aromatic rings are excluded. Which has an excellent antitumor activity. |
申请人 |
EISAI CO., LTD. |
发明人 |
SUGUMI, HIROYUKI;NIIJIMA, JUN;KOTAKE, YOSHIHIKO;OKADA, TOSHIMI;KAMATA, JUN-ICHI;YOSHIMATSU, KENTARO;NAGASU, TAKESHI;NAKAMURA, KATSUJI;UENAKA, TOSHIMITSU;YAMAGUCHI, ATSUMI;YOSHINO, HIROSHI;KOYANAGI, NOZOMU;KITO, KYOSUKE |