发明名称 |
Cell line for propagating receptor binding site-deleted FMDV |
摘要 |
A method of making a genetically-engineered cell line which is susceptible to infection by foot-and-mouth disease virus and allows the virus to replicate is disclosed. The method involves fusing the DNA encoding ICAM-1 with the DNA encoding an antibody specific for foot-and-mouth disease virus and expressing the resulting chimeric cell surface receptor protein. The chimeric cell surface receptor protein allows foot-and-mouth disease virus to bind, leading to subsequent infection and replication of foot-and-mouth disease virus. A genetically-engineered cell which expresses the chimeric cell surface receptor protein is also claimed.
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申请公布号 |
US5866416(A) |
申请公布日期 |
1999.02.02 |
申请号 |
US19960593999 |
申请日期 |
1996.06.24 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE |
发明人 |
MASON, PETER W.;BAXT, BARRY;REIDER, ELIZABETH;BERINSTEIN, ANALIA;KANG, ANGRAY S. |
分类号 |
A61K39/00;C07K14/09;C07K14/705;(IPC1-7):A61K39/135;C07H21/04;C12N5/10 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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