Method for controlling the fidelity and the execution of reverse transcriptase by incorporating and polymerising nucleotide analogues accepted as substrates of the reverse transcription response without blocking its elongation

摘要

The invention concerns the use of nucleotide analogues, defined as molecules acceptable as substrate of the reverse-transcription response and enabling the addition of at least one supplementary nucleotide to the polynucleotide chain during synthesis to affect and/or take over control of the fidelity and execution of the reverse transcription. The invention also concerns a pharmaceutical composition containing said nucleotide analogues.