发明名称 |
B RING REDUCED-D RING OXIDIZED TETRAPYROLLIC PHOTOSENSITIZERS FOR PHOTODYNAMIC THERAPY AND TUMOR IMAGING |
摘要 |
Tetrapyrollic photo sensitizers and imaging agent compounds having A, B, C, and D rings and having a reduced B ring and an oxidized D ring. The compounds preferably have a purity of at least 95 percent and preferably have a fused system connected at an unsaturated carbon atom of the C ring nearest the D ring and at the unsaturated carbon atom between the C and D rings. The invention also includes a method of making the compounds at over 95 percent yield by starting with a B and D ring oxidized tetrapyrollic compound and dissolving it in a halogenated hydrocarbon solvent and treating it with sufficient nitroalkane solution of FeCl36H2O to oxidize the D ring and separating the resulting organic layer and drying. |
申请公布号 |
CA2715747(C) |
申请公布日期 |
2016.05.24 |
申请号 |
CA20092715747 |
申请日期 |
2009.02.19 |
申请人 |
HEALTH RESEARCH, INC. |
发明人 |
LIU, CHAO;DOBHAL, MAHABEER;POTTER, WILLIAM;MORGAN, JANET;OSEROFF, ALLAN;PANDEY, RAVINDRA K. |
分类号 |
C07D487/22;A61K31/409;A61K31/555;A61K41/00;A61K49/00;A61K51/00;A61P35/00 |
主分类号 |
C07D487/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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