X-OPTOGENETICS / U-OPTOGENETICS

摘要

Methods and systems for performing optogenetics using X-rays or ultrasound waves are provided. Visible-light-emitting nanophosphors can be provided to a sample, and X-ray stimulation can be used to stimulate the nanophosphors to emit visible light. Alternatively, ultrasonic waves can be provided to the sample to cause sonoluminescence, also resulting in emission of visible light, and this can be aided by the use of a chemiluminescent agent present in the sample. The emitted light can trigger changes in proteins that modulate membrane potentials in neuronal cells.

主权项

1. A method of performing optogenetics, comprising:
providing light-emitting particles to a sample; and providing X-rays to the sample such that the X-rays cause the light-emitting particles to emit light, thereby changing the membrane potential of a neuron within the sample.