Nanoparticle Diagnostic and Methods for Treating Disease

摘要

The present invention relates to the use of in vivo contrast agents in medical imaging in order to diagnose and treat disease, and to monitor and assess disease progression following treatment with a nanoparticle therapeutic agent comprising an active pharmaceutical agent. The present invention also relates to modulating nanoparticle tumor concentration by modulating the PEG density of the nanoparticles.

主权项

1. A method of selecting a subject to be treated with a nanoparticle therapeutic agent (NTA), the method comprising:
(a) administering a contrast agent to the subject; (b) measuring the level of accumulation of the contrast agent at at least one intended site of treatment; and (c) selecting the subject for NTA treatment based on the level of the accumulation of the contrast agent; wherein the intended site of treatment is a tumor.