发明名称 METHODS AND COMPOSITIONS FOR TREATING CARDIOVASCULAR DISORDERS
摘要 The invention generally relates to methods of treating a patient having, and/or at risk of, cardiovascular or cerebrovascular disorders. Such methods may include administering a MetAP2 inhibitor at a dose that does not substantially modulate angiogenesis.
申请公布号 US2016166531(A1) 申请公布日期 2016.06.16
申请号 US201514800128 申请日期 2015.07.15
申请人 Zafgen, Inc. 发明人 Hughes Thomas E.
分类号 A61K31/336;A61K45/06 主分类号 A61K31/336
代理机构 代理人
主权项 1. A method of treating, or minimizing the risk of, cardiovascular or cerebrovascular disease in a patient in need thereof, comprising administering to said patient an therapeutically effective amount of O-(4-dimethylaminoethoxycinnamoyl)fumagillol or pharmaceutically acceptable salts thereof thereby increasing serum levels of high density lipoproteins in said patient, wherein said therapeutically effective amount does not substantially modulate or suppress angiogenesis and wherein the patient is suffering from diabetes, thereby treating, or minimizing the risk of, cardiovascular or cerebrovascular disease in said patient.
地址 Boston MA US