STABILIZATION OF NUCLEIC ACIDS IN URINE

摘要

A composition and method for preserving a urine sample and a preservative delivery vessel are disclosed wherein treatment of the urine sample aids in preserving circulating cell-free nucleic acids in urine over a wide range of dilution ratios within temperature fluctuations that can occur during urine sample handling, storage and transportation. The urine sample preservation composition and method and preservative delivery vessel provide a method for obtaining high quality stabilized urinary cell-free nucleic acids for clinical diagnostics development and application.

主权项

1: A method for preserving a urine sample comprising the steps of:
(a) dispensing into a specimen container a predetermined amount of a urine preservative by removing the urine preservative from a sealed vessel; (b) contacting the urine preservative with a urine sample; (c) sealing the specimen container with the urine sample and the urine preservative contained within it; and (d) causing the sealed specimen container to be shipped to a clinical laboratory for analysis of the urine sample; wherein the urine sample, upon being preserved is capable of analysis after a period at least 168 hours has elapsed.