| 摘要 |
FIELD: biotechnology.SUBSTANCE: invention relates to biotechnology, specifically to prevention of undesired immune responses in mammals, and can be used in medicine. Method consists in (a) establishing at least one CD1d-binding motif of NKT cell epitope in peptide or polypeptide, wherein said epitope comprises the motif of [FWTHY]-XX-[ILMV]-XX-[FWTHY], wherein X, X, X, Xis any aminoacid, (b) removing said epitope by replacement of aminoacid residues in position P1 and/or P7 on non-hydrophobic residues; and (c) obtaining isolated peptide or a polypeptide with decreased ability to activate NKT cells in mammal.EFFECT: invention allows to reduce undesirable immune responses in mammals towards allofactors, towards viral vectors used for gene therapy and gene vaccination, towards proteins to which subjects are naturally exposed, towards genetically-modified organisms and towards undesirable effects related to vaccine administration for allergic or infectious diseases.10 cl, 3 dwg, 5 ex |
