Methods of making cell carrier

摘要

A method of making a carrier for growing cells, including providing a polymer film; embossing a patterned surface one or more sides of the polymer film with an embossing roller; generating a pattern of structured indentations on the polymer film; and discretizing the patterned polymer film into a plurality of portions. The embossing pattern generates relief features on the carrier surface. An alternative method of making a carrier is also provided, including extruding a polymer film; embossing a patterned surface on the polymer film with a roller; generating a pattern of structured indentations on the polymer film; imparting a surface treatment to the film; and discretizing the treated polymer film into a plurality of portions.

主权项

1. A method of making a carrier for growing cells, comprising:
a) providing a polymer film; b) embossing on at least two sides of the polymer film with at least two embossing rollers comprising a patterned surface, wherein a first roller of the at least two rollers comprises a first plurality of protrusions, and wherein a second roller of the at least two rollers comprises a second plurality of protrusions; c) generating a first pattern of structured indentations on a first side and second pattern of structured indentations on a second side opposing the first side of the at least two sides of the polymer film, wherein the first pattern is different than the second pattern and wherein the first roller of the at least two rollers comprises a plurality of protrusions of a first shape, and wherein the second roller of the at least two rollers comprises a plurality of protrusions of a second shape; and d) discretizing the patterned polymer film into a plurality of portions.