| 摘要 |
FIELD: chemical-and-pharmaceutical industry, biotechnology, medicine, in particular biologically active peptides with anti-microbial action. ^ SUBSTANCE: invention relates to peptides of general formula 1 (X1-Lys-Leu-X2-X3-X4-X5-X6-Arg-Lys-Ala-Ile-Ser-Tyr-Ala-Val-Lys-Ala-X2 (1) obtained by modification of starting structure of latarcin peptide, wherein X1 is absent or is glycine residue (Gly), or Phe-Gly dipeptide, or Leu-Phe-Gly tripeptide, or Gly-Leu-Phe-Gly tetrapeptide; X2 is glutamine residue (Gln) or isoleucyne residue (Ile); X3 is arginine residue (Arg) or lysine residue (Lys); X4 is arginine residue (Arg) or lysine (Lys) residue; X5 is lysine residue (Lys) or phenylalanine residue (Phe); X6 is glycine residue (Gly) or leucine residue (Leu); X7 is absent or is arginine residue (Arg), or Arg-Gly dipeptide, or Arg-Gly-Lys tripeptide, or Arg-Gly-Lys-His tetrapeptide, or Arg-Gly-Lys-Asn tetrapeptide. ^ EFFECT: new peptide with anti-microbial activity. ^ 7 ex, 4 tbl, 3 dwg |
