发明名称 |
TREATING INFLAMMATION USING LLP2A-BISPHOSPHONATE CONJUGATES AND MESENCHYMAL STEM CELLS |
摘要 |
The present invention provides methods of treating a subject having a primary inflammatory disease or disorder comprising administering to the subject a composition comprising a conjugate of an LLP2A peptidomimetic ligand and a bisphosphonate drug, wherein the composition comprising the LLP2A-bisphosphonate conjugate enhances the delivery of mesenchymal stem cells to a site of inflammation. Methods of enhancing an anti-inflammatory or immunomodulatory property of mesenchymal stem cells, comprising administering to a subject in need thereof the mesenchymal stem cells and a composition comprising a conjugate of an LLP2A peptidomimetic ligand and a bisphosphonate drug, are also provided. |
申请公布号 |
EP3052104(A1) |
申请公布日期 |
2016.08.10 |
申请号 |
EP20140850853 |
申请日期 |
2014.10.03 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
LANE, NANCY E.;LIU, RUIWU;YAO, WEI;LAM, KIT S. |
分类号 |
A61K31/663;A61P19/02;A61P19/08;C12N5/077 |
主分类号 |
A61K31/663 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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