发明名称 |
NOVEL TRIAZINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME |
摘要 |
Disclosed is a novel compound having P2X3 or P2X2/3 receptor antagonistic effect. Specifically disclosed is a compound represented by formula (I). (In the formula, (a) R a and R b combine together to form =Z, and R c is a group represented by R1c, or alternatively (b) R b and R c combine together to form a bond, and R a is a group represented by -Y-R1a; R1a and R1c each independently represents a hydrogen atom, a substituted or unsubstituted alkyl group or the like; R2 and R3 each independently represents a substituted or unsubstituted aryl group or the like; R4a and R4b each independently represents a hydrogen atom, a substituted or unsubstituted alkyl group or the like; X represents -N(R5)- or the like; R5 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group or the like; Y represents -O- or the like; Z represents =O or the like; and n represents an integer of 0-4.) |
申请公布号 |
CA2752269(C) |
申请公布日期 |
2016.08.30 |
申请号 |
CA20102752269 |
申请日期 |
2010.02.10 |
申请人 |
SHIONOGI & CO., LTD. |
发明人 |
KAI, HIROYUKI;KAMEYAMA, TAKAYUKI;HASEGAWA, TSUYOSHI;OOHARA, MIHO;TADA, YUKIO;ENDOH, TAKESHI |
分类号 |
C07D251/46;A61K31/53;A61K31/5377;A61P13/08;A61P13/10;A61P21/00;A61P25/00;A61P25/02;A61P25/06;A61P25/08;A61P29/00;A61P43/00;C07D251/52;C07D401/06;C07D401/12;C07D401/14;C07D403/04;C07D403/06;C07D403/12;C07D405/06;C07D405/12;C07D409/06;C07D413/12 |
主分类号 |
C07D251/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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