Closed loop control system based on a non-invasive continuous sensor

摘要

Methods and systems for controlling analyte levels are described. An example method may include receiving a sensor measurement relating to an eye-mountable device. The method also may include determining an analyte concentration based on the one or more sensor measurements, and comparing the analyte concentration to a target analyte concentration. Based on the comparing, the method further may include providing instructions to a drug delivery device, where the instructions are configured to control a drug delivery rate by the drug delivery device.

主权项

1. A system comprising:
an eye-mountable device including a polymeric material; an electrochemical sensor mounted in the eye-mountable device, wherein the electrochemical sensor provides one or more sensor measurements indicative of glucose concentration in a tear-film contacting the eye-mountable device; a reader including one or more antennas, wherein the reader: (i) transmits radio frequency (RF) radiation to power the eye-mountable device and the electrochemical sensor, and (ii) receives indications of the one or more sensor measurements; and a controller in communication with the reader, wherein the controller: (i) receives information related to the one or more sensor measurements from the reader; (ii) obtains a target value for glucose concentration in the tear-film; (iii) compares the glucose concentration in the tear-film to the target value for glucose concentration in the tear-film; and (iv) based on the comparing, provides instructions to an insulin delivery device to control an insulin delivery rate to a blood stream by the insulin delivery device so as to reduce discrepancy between the glucose concentration in the tear-film and the target value for glucose concentration in the tear-film.