| 发明名称 | Methods and compositions for eliciting an immune response against hepatitis B virus | ||
| 摘要 | The present invention relates to immunization of hypo-responsive groups of individuals. In particular, the present invention provides methods and compositions for eliciting a potent immune response to hepatitis B virus in individuals in need thereof. | ||
| 申请公布号 | US9452212(B2) | 申请公布日期 | 2016.09.27 |
| 申请号 | US201213448302 | 申请日期 | 2012.04.16 |
| 申请人 | Dynavax Technologies Corporation | 发明人 | Heyward William L. |
| 分类号 | A61K39/29;A61K39/12;C12N15/86;A61K39/42;C07K16/08;C12N15/113;A61K39/00;C12N7/00;A61K31/713 | 主分类号 | A61K39/29 |
| 代理机构 | Morrison & Foerster LLP | 代理人 | Morrison & Foerster LLP |
| 主权项 | 1. A method for eliciting a seroprotective immune response against hepatitis B virus (HBV) in a human subject with type II diabetes and without chronic kidney disease, comprising: administering to the human subject a first and a second dose of an immunogenic composition comprising a hepatitis B surface antigen (HBsAg) and an immunostimulatory sequence (ISS) present in said immunogenic composition in amounts effective to elicit a seroprotective immune response comprising an anti-HBsAg concentration of at least 10 mIU/mL in the subject at one month after only two doses, wherein said ISS is single stranded and consists of the nucleotide sequence of SEQ ID NO:1, and wherein said immunogenic composition comprises from about 10 to about 20 μg of said HBsAg and from about 1000 to about 3000 μg of said ISS. | ||
| 地址 | Berkeley CA US | ||