BTK INHIBITORS

摘要

The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I or pharmaceutically acceptable salts thereof. Formula I or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds in the treatment of Btk mediated disorders.;

主权项

1. A compound according to Formula I, or a pharmaceutically acceptable salt thereofwherein:
R1 is halogen; R2 is H is selected from the group consisting of
a) OH;b) (1-6C)alkyl;c) (3-6C)cycloalkyl;d) (1-6C)alkoxy;e) (1-3C)heterocycloalkyl; andf) (1-3C)heteroaryl;g) (2-4C)alkenyl; andh) (2-4C)alkynyl; R2 is optionally substituted with one, two or three groups selected from: halogen, (1-6C)alkyl, (1-6C)alkoxy, hydroxy or cyano; R3 is H or (1-3C)alkyl; R2 and R3 together can form a saturated heterocyclic 5- or 6-membered ring; and x is 1, 2 or 3.