METHOD OF PREPARING VERY SLIGHTLY SOLUBLE DRUG WITH SOLID DOSAGE FORM

摘要

A method of preparing a very slightly soluble drug with solid composition includes the following steps: (a) adding a very slightly soluble drug into an organic solvent and polysorbate to form a first solution; (b) adding the first solution into a second solution and a pharmaceutically acceptable excipient, wherein the second solution comprises water or SLS, and a volume ratio of the first solution and the second solution is between 8:1 and 1:1; and (c) drying and compressing the mixture in step (b) to form a very slightly soluble drug with solid composition.

主权项

1. A method of preparing a very slightly soluble drug with a solid dosage form including the following steps:
(a) Adding a very slightly soluble drug into an organic solvent and a polysorbate to form a first solution; (b) Adding the first solution into a second solution and at least one pharmaceutically acceptable excipient, wherein the second solution comprises water or sodium lauryl sulfate (SLS), and a volume ratio of the first solution and the second solution is between 8:1 and 1:1; and (c) Drying and compressing the mixture in step (b) to form a very slightly soluble drug with a solid dosage form.