| 摘要 |
<p>The invention is an improved method for the preparation of tertiary phosphines by way of cross-coupling of aryl, alkenyl, cycloalkenyl or aralkyl halides or aryl, alkenyl, cycloalkenyl or aralkyl sulfonate esters with chlorophosphines in the presence of a catalyst and a reductant. In general reaction scheme (I), R1 is aryl, alkenyl, cycloalkenyl or aralkyl, any of which may be substituted by one or more of the following: alkyl, aryl, aralkyl, alkoxy, alkanoyl, chloro, fluoro, alkoxycarbonyl, cyano, trifluoromethyl, cycloalkyl, or CONR4R5 wherein R?4 and R5¿ are independently hydrogen, alkyl, aryl or aralkyl; R?2 and R3¿ are independently aryl, alkyl, aralkyl, any of which may be substituted by one or more of the following: alkyl, aryl, arylkyl, alkoxy, alkanoyl, chloro, fluoro, alkoxycarbonyl, cyano, trifluoromethyl, cycloalkyl or CONR4R5 wherein R?4 and R5¿ are independently hydrogen, alkyl, aryl or aralkyl; and n is 2 where R1 is a difunctional moiety and 1 for any other R1; and X isC1, Br, I, or OSO¿2?Y; wherein Y is alkyl, trihalomethyl, phenyl, halophenyl, or alkylphenyl.</p> |
