发明名称 |
Acute phase protein modulating endotoxic activity of lipopolysaccharides, assay methods and polypeptides |
摘要 |
A lipopolysaccharide binding protein is disclosed as are an assay method, polypeptides and antibodies related to that binding protein. The binding protein: (a) is present in impure form in acute phase serum, but is substantially absent from normal serum; (b) binds to Gram-negative bacterially secreted lipopolysaccharide in vitro in the serum of the animal treated; (c) retards in vitro binding of the lipopolysaccharide to high density lipoprotein present in the normal serum of the animal host; and (d) immunoreacts with antibodies raised to a polypeptide having the amino acid residue sequence, from left to right and in the direction from amino-terminus to carboxy-terminus, or <IMAGE> wherein each of said parenthesized amino acid residues is an alternative to the immediately preceding residue in said sequence.
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申请公布号 |
US5871937(A) |
申请公布日期 |
1999.02.16 |
申请号 |
US19970990849 |
申请日期 |
1997.12.15 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
ULEVITCH, RICHARD J.;TOBIAS, PETER S. |
分类号 |
A61K38/00;C07K14/47;G01N33/569;(IPC1-7):G01N33/53;G01N33/52 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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