4-(SUBSTITUTED ARYL)-5-HYDROXYISOQUINOLINONE DERIVATIVE

摘要

The invention provides 4-substituted aryl-5-hydroxyisoquinolinone derivatives and their pharmacologically acceptable addition salts with excellent inhibitory effect on poly (ADP-ribose) synthetase. <??>4-Substituted aryl-5-hydroxyisoquinolinone derivatives, represented by a general formula (1) <CHEM> and their pharmacologically acceptable addition salts.