New antibody (which specifically recognizes human thiamine 1) useful for blocking the binding of human Thy-1 at its ligand or for blocking the interaction of tumor cells or immune cells with endothelial cells

摘要

Antibody (I), which specifically recognizes human thiamine 1 (Thy-1) (CD90), for blocking the binding of human Thy-1 at its ligand, is new. Independent claims are also included for: (1) (I) obtained from hybridoma-cell line with the deposit number of DSM ACC2690; (2) hybridoma-cell line with the deposit number DSM ACC2690; (3) preparation of monoclonal antibodies against human Thy-1 comprising immunising BALB/c mice with human Thy-1, fusing its spleen cells, selecting the antibody producing hybridoma in a selective medium, cloning and far increasing the reactive and specific hybridoma by cultivation, where hybridoma-cell line with the deposit number DSM ACC2690 is used for cultivation and antibody production; (4) immunological test kit comprising at least (I) or a product derived from it; and (5) pharmaceutical preparation comprising (I) or a product derived from it. ACTIVITY : Cytostatic; Antiarthritic; Antiinflammatory; Antipsoriatic; Antirheumatic. No biological data given. MECHANISM OF ACTION : None given.