INDOLIZINE ACETIC ACID DERIVATIVES AS CRTH2 ANTAGONISTS

摘要

The specific compounds of this list : {7-cyano-2-methyl-1-[4-(morpholine- 4-sutfonyl)benzyl]indolizin-3-yl}acetic acid, {1 -(3-chloro-4-ethanesulfonyl benzyl)-7-cyano-2-methylindolizin-3-yl}acetic acid, {1-[3-chloro4-(morpholin e-4-sulfonyl)benzyl]-7-cyano-2-methylindolizin-3-yl}acetic acid, {1-(3-chlor o-4-ethanesulfonylphenylsulfanyl)-7-cyano-2-methylindolizin-3-yl}acetic acid , {1-[3-chloro-4-(morpholine-4-sutfonyl)phenylsutfanyl]-7-cyano-2-methylindo lizin-3- yl}acetic acid, {7-cyano-1 -(6-fluoroquinolin-2-y1methyl)-2-methyli ndolizin-3-yl}acetic acid are ligands of the CRTH2 receptor and are useful i n the treatment of respiratory diseases.