dispositivo para determinar a cardiotoxidade de um composto químico, método para fabricação de dispositivo, método de determinação da cardiotoxidade de um composto químico e uso do dispositivo

摘要

Disclosed is a device for determining the cardiotoxicity of a chemical compound comprising a substrate (10) carrying a deformable stack (34), said stack being partially detached from the substrate by a cavity (32) allowing an out-of-plane deformation of the stack, said stack comprising a first deformable layer (16), a second deformable layer (20) and a multi-electrode structure (18) sandwiched between the first and second deformable layers, the second deformable layer carrying a pattern of cardiomyocytes (28) adhered thereto; and a liquid container (26) mounted on the substrate for exposing the cardiomyocytes to the chemical compound. A method of manufacturing such a device is also disclosed.