| 摘要 |
The purpose of the present invention is to provide: a detection agent for specifically detecting cancer stem cells; a tumor antigen peptide specifically exhibited by cancer stem cells; a pharmaceutical composition for the prevention and/or treatment of cancer, containing same as an effective component thereof; and a method for screening said tumor antigen peptide. A peptide indicated by YO—XO—ZO, a polyepitope peptide including at least one said peptide as an epitope peptide and having a plurality of epitope peptides joined therein, a polynucleotide that codes at least either the peptide or the polyepitope peptide, a pharmaceutical composition containing these as an effective component thereof, and a cancer prevention and/or treatment agent characterized by inducing CTLs. |
| 主权项 |
1. A peptide represented by Y0—X0—Z0,
X0 being any of (1) to (4) below: (1) a partial peptide of a FAM83B protein consisting of 8 to 14 consecutive amino acids in the amino acid sequence of the protein, the second amino acid from the N terminal being leucine, isoleucine, or methionine, and/or the amino acid at the C terminal being valine, leucine, or isoleucine; (2) a peptide which, in the partial peptide of (1), the second amino acid from the N terminal being replaced by leucine, isoleucine or methionine, and/or the amino acid at the C terminal being replaced by valine, leucine or isoleucine; (3) a partial peptide of the FAM83B protein consisting of 8 to 14 consecutive amino acids in the amino acid sequence of the protein, the second amino acid from the N terminal being tyrosine, phenylalanine, methionine, or tryptophan, and/or the amino acid at the C terminal being leucine, isoleucine, or phenylalanine; or (4) a peptide which, in the partial peptide of (3), the second amino acid from the N terminal being replaced by tyrosine, phenylalanine, methionine or tryptophan, and/or the amino acid at the C terminal being replaced by leucine, isoleucine or phenylalanine; and Y0 and Z0 mutually independently being a peptide consisting of 0 to several amino acids. |
