Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.
申请公布号
AU2011336727(B2)
申请公布日期
2016.11.03
申请号
AU20110336727
申请日期
2011.11.29
申请人
The Johns Hopkins University
发明人
Liu, Jun O.;Wang, Jingxin;Guo, Zufeng;Li, Wei;Bhat, Shridhar;Das, Manisha