发明名称 |
Recombinant Newcastle disease virus expressing H5 hemagglutinin of avian influenza virus |
摘要 |
<p>The present invention provides a method to produce a recombinant Mononegavirales virus vector harbouring an additional transcription unit comprising a foreign gene operatively linked with an upstream Mononegavirales virus gene start (GS) sequence and a downstream Mononegavirales virus gene end (GE) sequence, characterized in that the foreign gene sequence encodes a protein, which protein contains a stretch of at least three basic amino acids and the nucleotide sequence of the codons encoding these amino acids does not contain a sequence that can be recognized by the viral polymerase of the Mononegavirales virus as a gene end (GE) sequence.</p> |
申请公布号 |
AU2007224430(A1) |
申请公布日期 |
2007.09.20 |
申请号 |
AU20070224430 |
申请日期 |
2007.03.15 |
申请人 |
INTERVET INTERNATIONAL B.V. |
发明人 |
ANGELA ROMER-OBERDORFER;JUTTA VEITS |
分类号 |
C07K14/11;C12N15/86 |
主分类号 |
C07K14/11 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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