Device and method for intraocular drug delivery

摘要

Devices for delivering pharmaceutical formulations into the eye are described. The devices may be integrated to include features that allow safe and atraumatic manipulation of the devices with one hand. For example, accurate placement, including proper angulation, of the device on the eye and injection of a pharmaceutical formulation into the eye can be performed using one hand. The devices may also include improved safety features. For example, the devices may include an actuation mechanism that controls the rate and depth of injection into the eye. Some devices include a dynamic resistance component capable of adjusting the amount of pressure applied to the eye surface. Related methods and systems comprising the devices are also described.

主权项

1. An injection device for intraocular drug delivery comprising:
a housing having a proximal end and a distal end; a conduit having a proximal end and a distal end, the proximal end of the conduit proximate and fluidly connected to an input port; a dynamic sleeve concentrically disposed about the conduit and the housing and having a distal end and a fixed axial length; an arcuate atraumatic ocular contact surface at the dynamic sleeve distal end; a measuring component comprising a plurality of measuring members extending radially from a perimeter of the arcuate atraumatic ocular contact surface, the plurality of measuring members spaced apart from each other, the plurality of measuring members comprising the same size and shape; wherein the dynamic sleeve is movable between a first configuration in which the conduit extends distally beyond the dynamic sleeve distal end for intraocular injection and a second configuration in which the conduit is retracted completely within the dynamic sleeve distally and within the housing proximally; and wherein the housing, the conduit and the dynamic sleeve are combined into a single integrated device.