NOVEL PYRIDYLOXYACETYL TETRAHYDROISOQUINOLINE COMPOUNDS USEFUL AS NAMPT INHIBITORS

摘要

The present invention provides novel pyridyloxyacetyl tetrahydroisoquinoline compounds that inhibit NAMPT and may be useful in the treatment of cancer.

主权项

1. A compound of the following formula: wherein: R1 is —NHSO2R2, —NHC(O)CH2R3, —CH2-piperazinyl-C(O)R4, or —CH(CH3)-piperazinyl-C(O)R4; R2 is N-methylpiperidin-4-yl, N-oxetan-3-yl-piperidin-4-yl, tetrahydropyran-4-yl, tetrahydropyran-4-yl-N-carbonyl-piperidin-4-yl, 2-hydroxy-2-methyl-prop-1-yl, methoxyethyl, 2-isopropoxyethyl, 2-trifluoromethylethyl, cyclopropylmethyl, or pyrid-2-yl; R3 is tetrahydropyran-2-yl, t-butyl, —CH(CH3)(CH3)(OH), —C(OH)(CH3)(CH2CH3), or —C(OH)(CH3)(CF3); and R4 is tetrahydropyran-4-yl, tetrahydropyran-4-yl-methyl, morpholin-4-yl-methyl, or 2-hydroxy-2-methyl-propyl; or a pharmaceutically acceptable salt thereof.