PHOTOREACTIVE SYNTHETIC REGULATOR OF PROTEIN FUNCTION AND METHODS OF USE THEREOF

摘要

The present disclosure provides a photoreactive synthetic regulator of protein function. The present disclosure further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present disclosure further provides methods of modulating protein function, involving use of light.

主权项

1. A synthetic regulator of polypeptide function, the regulator having the formula: (A)n-X1-(B)m-X2-(C)p, wherein
A is a polypeptide association moiety; B is a photoisomerizable group; C is a ligand; each of n, m, and p is independently an integer from 1 to 10; X1, when present, is a spacer; and X2, when present, is a spacer.