摘要 |
The present invention relates to a novel a process for the preparation of 9--dichloromethylene-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-ylamine which process comprises a) reacting cyclopentadiene in the presence of a radical initiator and CXCI3, wherein X is chloro or bromo, to a compound of formula I1, or aa) reacting cyclopentadiene with CXCI3, wherein X is chloro, in the presence of a metal catalyst to a compound of formu-la I1, wherein X is chloro, b) reacting the compound of formula I1 with a base in the presence of an appropriate solvent to the compound of formula III, c) and converting the compound of formula III in the presence of 1,2-dehydro-6- nitrobenzene to the compound of formula IV, and d) hydrogenating the compound of formula IV in the presence of a metal catalyst. |
申请人 |
SYNGENTA PARTICIPATIONS AG |
发明人 |
GRIBKOV, DENIS;ANTELMANN, BJOERN;GIORDANO, FANNY;WALTER, HARALD;DE MESMAEKER, ALAIN |