发明名称 |
HEPATIC ARTERIAL INFUSION OF CAR-T CELLS |
摘要 |
Disclosed herein are compositions and methods for the treatment of liver metastases in a subject. The methods include hepatic arterial infusion (HAI) of chimeric antigen receptor modified T cells (CAR-T) which are highly specific for tumor antigens such as carcinoembryonic antigen (CEA). The HAI method is optimized to maximize exposure of the modified cells to the metastatic cells while minimizing exposure to healthy cells. The methods include co-administration of a second therapeutic agent, such as IL-2. |
申请公布号 |
WO2016168493(A1) |
申请公布日期 |
2016.10.20 |
申请号 |
WO2016US27582 |
申请日期 |
2016.04.14 |
申请人 |
PROSPECT CHARTERCARE RWMC, LLC D/B/A ROGER WILLIAMS MEDICAL CENTER |
发明人 |
KATZ, Steven C.;JUNGHANS, Richard |
分类号 |
A61K35/17;A61P35/00;C07K16/30;C12N5/10 |
主分类号 |
A61K35/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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