发明名称 1' -substituted carba-nucleoside analogs for antiviral treatment
摘要 Provided are pyrrolo[ 1,2-fl [1,2,4]triazinyl, imidazo[ 1,5-fl [1,2,4]triazinyl, imidazo[ 1,2 f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof, wherein the I 'position of the nucleoside sugar is substituted. The 5 compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections. Formula (I), each X or X2 is independently C-R 10or N. Fonnula I
申请公布号 AU2016250419(A1) 申请公布日期 2016.11.17
申请号 AU20160250419 申请日期 2016.10.27
申请人 Gilead Sciences, Inc. 发明人 Saunders, Oliver L.;Zhang, Lijun;Butler, Thomas;Kim, Choung U.;Cho, Aesop;Parrish, Jay
分类号 C07D487/04;A61K31/395;A61K31/41;A61K31/4188;A61K31/7052;A61P31/12;C07H19/23 主分类号 C07D487/04
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