METHOD AND DEVICE FOR THE IN VITRO ANALYSIS OF MRNA OF GENES INVOLVED IN HAEMATOLOGICAL NEOPLASIAS

摘要

The invention relates to a method and device for the in vitro analysis of mRNA of genes involved in haematological neoplasias. The inventive device, which comprises probes which specifically hybridise with genes involved in haematological neoplasias and which are designed such as to perform in a similar manner in the hybridisation, can be used to evaluate the level of mRNA in biological samples taken from subjects suspected of having a haematological neoplasia and to facilitate the comparison of different samples and the grouping of said samples according to similarity in the gene expression patterns, especially when the probes are disposed in the form of a microarray. The inventive method can be used to obtain and process data from the device relating to differences in gene expression such as to identify significant genes in order to distinguish samples that are associated with haematological neoplasias. In addition, the method facilitates the diagnosis of neoplasias such as LLC and the prognosis of the development of same.