发明名称 |
METHOD FOR DETECTING PROTEASES AND ACTIVE INFECTION IN BIOLOGICAL FLUIDS AND TISSUES |
摘要 |
Electrochemical biosensing devices (200, 300, 400) and methods detect the activity of proteases and active infection in biological samples. The devices and methods utilize distance constraints between a redox reporter (204, 305, 404) and an electrode (206, 306, 406) to create a change in current that is detected. The distance constraints are released when an analyte containing a specified protease or proteases reacts with a protein substrate sequence in the analyte. The particular protease or proteases to be detected can be selected by using biosensors with particular substrate sequences. The devices and methods are not only qualitative, they can be used to quantitatively evaluated protease content in samples. |
申请公布号 |
WO2016061590(A9) |
申请公布日期 |
2016.10.20 |
申请号 |
WO2015US56284 |
申请日期 |
2015.10.19 |
申请人 |
WARDELL, Mark, R.;SABACINSKI, Kenneth, A. |
发明人 |
WARDELL, Mark, R.;SABACINSKI, Kenneth, A. |
分类号 |
C12Q1/68;C12N15/00;G01N27/327 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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地址 |
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