发明名称 |
PROCESS FOR PRODUCING OPTICALLY ACTIVE alpha-METHYLCYSTEINE DERIVATIVE |
摘要 |
<p>The present invention provides a simple industrial process for producing an L- or D-optionally active alpha -methylcysteine derivative or its salt, which is a useful pharmaceutical intermediate, from readily available, inexpensive raw materials. <??>In a process for producing an L- or D-optically active alpha - methylcysteine derivative or its salt, a racemic N-carbamoyl- alpha - methylcysteine derivative or its salt is D-selectively cyclized with hydantoinase to produce a D-5-methyl-5-thiomethylhydantoin derivative or its salt and an N-carbamoyl- alpha -methyl-L-cysteine derivative or its salt, which are then subjected to deprotection of the amino group and the sulfur atom, and hydrolysis.</p> |
申请公布号 |
EP1550725(A1) |
申请公布日期 |
2005.07.06 |
申请号 |
EP20030730820 |
申请日期 |
2003.06.05 |
申请人 |
KANEKA CORPORATION |
发明人 |
OHISHI, TAKAHIRO;NANBA, HIROKAZU;SUGAWARA, MASANOBU;IZUMIDA, MASASHI;HONDA, TATSUYA;MORI, KOHEI;YANAGISAWA, SATOHIRO;NAGASHIMA, NOBUO;INOUE, KENJI |
分类号 |
C12P13/12;C07C319/02;C07C319/06;C07C319/14;C07C323/58;C07D233/76;C12P17/04;C12P17/10;C12P41/00;(IPC1-7):C12P13/12 |
主分类号 |
C12P13/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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