| 发明名称 | Polypeptide | ||
| 摘要 | The invention relates to a polypeptide, a corresponding nucleic acid molecule, a construct and/or vector and/or cell comprising such nucleic acid molecule and/or a composition comprising said polypeptide, nucleic acid molecule, construct, vector and/or cell. The invention further relates to such composition for medical use, preferably for use in treating an infectious disease. Furthermore, the invention relates to the use of said polypeptide, nucleic acid molecule, construct, vector, cell and/or composition as an antimicrobial, preferably as a food additive or disinfectant, or for detecting bacteria, preferably in a diagnostic application. | ||
| 申请公布号 | US9382298(B2) | 申请公布日期 | 2016.07.05 |
| 申请号 | US201114115609 | 申请日期 | 2011.05.04 |
| 申请人 | Micreos Human Health B.V. | 发明人 | Loessner Martin Johannes;Eichenseher Fritz |
| 分类号 | C07K14/31;C12N9/36;G01N33/569 | 主分类号 | C07K14/31 |
| 代理机构 | McDonnell Boehnen Hulbert & Berghoff LLP | 代理人 | McDonnell Boehnen Hulbert & Berghoff LLP |
| 主权项 | 1. A nucleic acid molecule comprising a first nucleotide sequence, encoding a cell wall-binding domain binding the peptidoglycan cell wall of Staphylococcus genera, said nucleic acid molecule further comprising a heterologous nucleotide sequence encoding a lytic domain exhibiting peptidoglycan hydrolase activity, wherein said lytic domain is a second and third nucleotide sequences, and wherein said second nucleotide sequence encodes an M23 endopeptidase domain and said third nucleotide sequence encodes an amidase domain, and wherein said nucleic acid molecule has at least 85% sequence identity with SEQ ID NO: 9. | ||
| 地址 | Wageningen NL | ||