Processes for the manufacture of a pharmaceutically active agent

摘要

Disclosed herein are processes for the preparation of a pharmaceutically active agent and pharmaceutically acceptable salts thereof.

主权项

1. A process for preparing a compound of Formula I or a salt thereof,the process comprising the steps of:
(a) hydrogenating a compound of Formula IIIWith H2 in the presence of NH3 and a transition metal catalyst to form the compound of Formula IV;
(b) reacting a compound of Formula IVwith 3-(2,2,3,3-tetrafluoropropoxyl)-benzaldehyde in the presence of a solvent to form an imine-containing compound; and
(c) reducing the imine-containing compound by using a reducing agent to form the compound of Formula I.