Stabilized compositions of volatile alkylating agents and methods of using thereof

摘要

A composition and method for treatment of cancer. The composition for treating a skin disorder, comprising: a Nitrogen Mustard or an HX salt of the Nitrogen Mustard, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier that does not include petrolatum or ethanol does not include petrolatum or ethanol. The method comprises topically applying the composition of a Nitrogen Mustard or a HX salt of the Nitrogen Mustard to the affected skin, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier does not include petrolatum or ethanol.

主权项

1. A topical composition comprising:
(a) a bis-(2-chloroethyl)methylamine or a pharmaceutically acceptable salt thereof, wherein the bis-(2-chloroethyl)methylamine or pharmaceutically acceptable salt thereof is present in an amount of at least about 0.001% by weight of the composition; and (b) a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier comprises
(i) a compound of formula HOCH2CH2OCH2CH2OR79, wherein R79 is a linear alkyl group having from 1 to 6 carbon atoms;(ii) hydroxypropylcellulose;(iii) butylated hydroxytoluene, benzyl alcohol, sodium benzoate, parabens, or edetate disodium; and(iv) a secondary or tertiary alcohol having from 1 to 20 carbon atoms.