发明名称 |
Antibodies against insulin-like growth factor I receptor and uses thereof |
摘要 |
An antibody binding to IGF-IR, being of human IgG1 or IgG3 type and being glycosylated with a sugar chain at Asn297, said antibody being characterized in that the amount of fucose within said sugar chain is at least 99%, and in addition the amount of NGNA is 1% or less and/ or the amount of N-terminal alpha-1,3-galactose is 1% or less has improved properties in antitumor therapy. |
申请公布号 |
ZA200808597(B) |
申请公布日期 |
2009.11.25 |
申请号 |
ZA20080008597 |
申请日期 |
2008.10.08 |
申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
HANSEN, SILKE;KUENKELE, KLAUS-PETER;REUSCH, DIETMAR;SCHUMACHER, RALF |
分类号 |
C07K |
主分类号 |
C07K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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