发明名称 |
Sulfonamide-containing linkage systems for drug conjugates |
摘要 |
Sulfonamide-containing linkage systems for release of payload compounds from an attached targeting moiety in drug conjugates. The conjugates have the formula of [(P)-(L)]m-(T), wherein (P) is a payload compound, (L) is a linker, (T) is a targeting moiety and m is an integer from 1- to 10. Also provided are pharmaceutical compositions comprising such conjugates and there use in treating cancer. |
申请公布号 |
AU2014373574(A1) |
申请公布日期 |
2016.07.14 |
申请号 |
AU20140373574 |
申请日期 |
2014.12.29 |
申请人 |
ZYMEWORKS INC. |
发明人 |
WINTERS, GEOFFREY C.;MANDEL, ALEXANDER L.;BOURQUE, ELYSE MARIE JOSEE;RICH, JAMES R.;HSIEH, TOM HAN HSIAO |
分类号 |
A61K47/48;A61P35/00 |
主分类号 |
A61K47/48 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|