Described are improved disulfide-containing alkyne linking agents having have branched disulfides. The improved linking agents exhibit improved stability. The linking agents are useful for attachment of oligonucleotides to targeting groups or delivery agents.
申请公布号
WO2016149313(A1)
申请公布日期
2016.09.22
申请号
WO2016US22560
申请日期
2016.03.16
申请人
ARROWHEAD RESEARCH CORPORATION
发明人
ALMEIDA, Aaron;BLOKHIN, Andrei, V.;WAKEFIELD, Darren, H.;BENSON, Jonathan, D.;ROZEMA, David, B.
