| 发明名称 |
ACETYLCHOLINESTERASE-Fc DOMAIN FUSION PROTEIN |
| 摘要 |
Fusion polypeptides are provided including modified human Acetylcholinesterase conjugated to the Fc region of an immunoglobulin. Methods of preparing these polypeptide constructs and uses thereof as scavenging agents of organophosphate compounds are described. |
| 申请公布号 |
US2016289657(A1) |
申请公布日期 |
2016.10.06 |
| 申请号 |
US201615089738 |
申请日期 |
2016.04.04 |
| 申请人 |
The Israel Institute of Biological Research (IIBR) |
发明人 |
MAZOR Ohad;COHEN Ofer;NOY-PORAT Tal |
| 分类号 |
C12N9/18 |
主分类号 |
C12N9/18 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A fusion polypeptide comprising:
(a) an acetylcholinesterase (AChE) polypeptide component comprising a modified human AChE polypeptide having an amino acid sequence denoted by SEQ ID NO: 8 or variants thereof; and (b) a fragment crystallizable (Fc) domain of human IgG or variants thereof, wherein the fusion polypeptide retains the functional activity of human AChE. |
| 地址 |
Ness-Ziona IL |
