发明名称 |
BISPECIFIC ANTIGEN-BINDING CONSTRUCTS TARGETING HER2 |
摘要 |
Provided herein are biparatopic antigen-binding constructs that specifically bind HER2. The biparatopic antigen-binding constructs comprise one antigen-binding moiety that binds to ECD2 of HER2, a second antigen-binding moiety that binds to ECD4 of HER2, and an Fc. At least one of the antigen-binding moieties is an scFv. The biparatopic antigen-binding constructs can be used in the treatment of cancer. |
申请公布号 |
US2016289335(A1) |
申请公布日期 |
2016.10.06 |
申请号 |
US201415036176 |
申请日期 |
2014.11.27 |
申请人 |
ZYMEWORKS INC. |
发明人 |
Weisser Nina E.;NG Gordon Yiu Kon;Wickman Grant Raymond;Dixit Surjit Bhimarao;Escobar-Cabrera Eric |
分类号 |
C07K16/32;G01N33/574;A61K45/06;A61K39/395;A61K47/48;C07K16/30 |
主分类号 |
C07K16/32 |
代理机构 |
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代理人 |
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主权项 |
1. An antigen-binding construct comprising
a first antigen-binding polypeptide construct which monovalently and specifically binds a HER2 (human epidermal growth factor receptor 2) ECD2 (extracellular domain 2) antigen on a HER2-expressing cell; a second antigen-binding polypeptide construct which monovalently and specifically binds a HER2 ECD4 (extracellular domain 4) antigen on a HER2-expressing cell; first and second linker polypeptides, wherein the first linker polypeptide is operably linked to the first antigen-binding polypeptide construct, and the second linker polypeptide is operably linked to the second antigen-binding polypeptide construct; wherein the linker polypeptides are capable of forming a covalent linkage with each other, and wherein one or both of the first or the second antigen-binding polypeptide is an scFv. |
地址 |
Vancouver CA |