METHODS FOR TREATING MYELODYSPLASTIC SYNDROMES AND SIDEROBLASTIC ANEMIAS

摘要

In certain aspects, the present disclosure provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans. In some embodiments, the compositions of the disclosure may be used to treat or prevent sideroblastic anemias and myelodysplastic syndromes or one or more complications associated sideroblastic anemias and myelodysplastic syndromes.

主权项

1. A method for treating or preventing sideroblastic anemia in a human patient, comprising administering to a patient in need thereof a polypeptide comprising the amino acid sequence of SEQ ID NO: 44, and wherein the patient is on a dosing schedule that comprises administering from 0.75-1.75 mg/kg of the polypeptide to the patient.