发明名称 |
NOVEL DIHYDROPYRIDOISOQUINOLINONES AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS |
摘要 |
A compound according to Formula (I): wherein R1, LA, CyA, RA, R2, R3, and R4 are as described herein. The present invention relates to novel compounds according to Formula I that antagonize GPR84, a G-protein-coupled receptor that is involved in inflammatory conditions, and methods for the production of these novel compounds, pharmaceutical compositions comprising these compounds, and methods for the prevention and/or treatment of inflammatory conditions, pain, neuroinflammatory conditions, neurodegenerative conditions, infectious diseases, autoimmune diseases, endocrine and/or metabolic diseases, cardiovascular diseases, leukemia, and/or diseases involving impairment of immune cell functions by administering a compound of the invention. |
申请公布号 |
WO2016169911(A1) |
申请公布日期 |
2016.10.27 |
申请号 |
WO2016EP58607 |
申请日期 |
2016.04.19 |
申请人 |
GALAPAGOS NV |
发明人 |
MENET, Christel, Jeanne, Marie;DOYON, Julien, Georges, Pierre-Olivier;CLAES, Pieter, Isabelle, Roger;ALLART, Brigitte;DE WACHTER, Maxim, Maria, Paul;TRICARICO, Giovanni, Alessandro |
分类号 |
C07D471/04;A61K31/4375;A61P29/00;C07D519/00 |
主分类号 |
C07D471/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|