NOVEL COMPOUNDS

摘要

Compounds of formula (I):;;are described herein. Compounds of the disclosure are modulators of Kv3 channels and may be used in the prophylaxis or treatment of related disorders.

主权项

1. A method for the prophylaxis or treatment of schizophrenia, which comprises administering to a subject in need thereof a compound of formula (I): wherein: W is CRaRb or 0;
when W is CRaRb then Z is CH2;when W is O then Z is CF2; Ra and Rb are CH3 or taken together form a C3 spiro cycloalkyl;
wherein, when W is CRaRb, Z is CH2 and Ra and Rb are CH3:
Ring A is:  and Ring B is: or
Ring A is:  and Ring B is: wherein, when W is CRaRb, Z is CH2 and Ra and Rb taken together form a C3 spiro cycloalkyl:
Ring A is:  andRing B is:  andwherein, when W is O and Z is CF2:
Ring A is:  and Ring B is:or a pharmaceutically acceptable salt and/or solvate thereof.