发明名称 |
METHOD OF USING ADENOVIRAL VECTORS WITH INCREASED IMMUNOGENICITY IN VIVO |
摘要 |
The invention provides a method of inducing an immune response in a mammal. The method comprises administering to the mammal an adenoviral vector comprising (a) a subgroup C fiber protein wherein a native coxsackievirus and adenovirus receptor (CAR)-binding site is disrupted, (b) a subgroup C penton base protein wherein a native integrin-binding site is disrupted, and (c) a nucleic acid sequence encoding at least one antigen derived from an infectious agent other than an adenovirus which is expressed in the mammal to induce an immune response.
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申请公布号 |
US2008069836(A1) |
申请公布日期 |
2008.03.20 |
申请号 |
US20070678947 |
申请日期 |
2007.02.26 |
申请人 |
THE GOVERNMENT OF THE U.S.A., AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SER;AND HUMAN SERVICES;GENVEC, INC.;GENVEC, INC. |
发明人 |
NABEL GARY J.;CHENG CHENG;GALL JASON G.;WICKHAM THOMAS J. |
分类号 |
A61K39/00;A61P37/04;C12N15/63 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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