ADENOSINE DERIVATIVES FOR THE TREATMENT OF PAIN

摘要

Compounds of formula (I) are disclosed. Their use as medicaments is described, in particular for the treatment of pain or inflammation. In said Fomula, when X=Y=Z=OH, R₁ is OCH₂CF₂CF₃, phenoxy (substituted with 3-(4-trifluoromethylphenyl), 3,4-dichloro, (3-trifluoromethyl,4-fluoro), (3-trifluoromethyl,4-chloro), (3-chloro, 4-cyano), or 3,5-bis(trifluoromethyl)), 1-piperazinyl(4-(3,4-dichlorophenyl)), phenyl (substituted with 3,4-dichloro, 3,5-difluoro, 3,5-bis(trifluoromethyl) or 3,4,5-trifluoro) or 2-benzofuranyl; or when X=Y=OH and Z=OMe, R₁ is OCH₃, OCH₂CHF₂, OCH₂cyclopentyl, O-(2,5- difluorophenyl) or (S)-sec-butylamino; or when X=H and Y=Z=OH, R₁ is n-hexylamino or cyclopentylamino; or when (IV) X=Z=OH and Y=H, R₁ is cyclopentylamino;or a pharmaceutically acceptable salt thereof.