发明名称 |
Monoclonal Antibodies Against Prostate Specific Membrane Antigen (PSMA) Lacking in Fucosyl Residues |
摘要 |
The invention pertains to anti-PSMA antibodies that lack fucosyl residues. The antibodies of the invention exhibit increased antibody-dependent cellular cytotoxicity (ADCC) activity as compared to the fucosylated form of the antibodies. The invention also provides host cells that express the anti-PSMA antibodies that lack fucosyl residues, wherein the host cells are deficient for a fucosyl transferase. Methods of using the antibodies to inhibit the growth of PSMA+ cells, such as tumor cells, are also provided.
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申请公布号 |
US2009060908(A1) |
申请公布日期 |
2009.03.05 |
申请号 |
US20060918191 |
申请日期 |
2006.02.17 |
申请人 |
MEDAREX, INC. |
发明人 |
CARDARELLI JOSEPHINE M.;PASSMORE DAVID B.;ALBANESE JENNY;ZHU LEI |
分类号 |
A61K39/395;A61P31/00;C07K16/18;C12N5/06 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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