NEUROPEPTIDES AS MODULATORS FOR CELL DIFFERENTIATION AND PROLIFERATION

摘要

A medicament for treating tissue lesions, differentiation or granulation deficits and metabolic disturbances contains, as active agent, calcitonin-gene related peptide (CGRP) and/or substance P and/or neuropeptide Y (NPY) optionally with usual pharmaceutical inactive ingredients and/or carriers. In order to produce autologous tissue equivalents, precursor cells taken from a patient are cultivated in vitro under addition of CGRP and/or substance P and/or NPY. Such tissue equivalents are used, in accordance with the invention, as implants in the field of therapy of tissue defects, tissue lesions or granulation disturbances.